麻醉与神经发育可塑性研究组

麻醉与神经发育可塑性研究组

 

研究组组长

       

丁海雷M.D., Ph.D.

 

教育与研究背景

1997/07徐州医学院麻醉学专业（学士）

2000/07徐州医学院麻醉学专业（硕士）

2004/07 中国科学院上海生命科学院生理学专业（博士）

2004.11－2009.08 美国德州大学西南医学中心博士后

2009.09－2014.07 美国科罗拉多大学安舒茨医学校园研究员

2014.07－当前徐州医科大学麻醉学院教授

 

研究方向

全麻药的神经毒性机制及其防治研究 全球每年接受手术治疗的婴幼儿患者约350万，有超过2500万剖宫产手术，大部分婴幼儿患者和剖宫产手术是在全麻下进行的。婴幼儿神经系统发育期是神经系统最脆弱，最容易受到损害的时期。全身麻醉是否会影响婴幼儿患者的神经系统发育、是否影响小儿学习记忆（或智力）功能是一个被广泛关注的医学热点问题和社会问题。本课题组采用斑马鱼与鼠模式动物着重探讨胚胎与婴幼儿期全麻药神经毒性发生机制，为寻找防治全麻药神经毒性新途径提供理论依据，该研究对提高临床小儿麻醉的安全性具有重要的理论和临床意义。

 

 

 

 

课题组成员

       

王亚莉   实验室管家

 

       

梁向南     研究生

 

       

徐小班研究生

 

       

马敏研究生

 

       

殷艺娜 研究生

 

 

发表文章

1. Pan Z, Zhang M, Ma T, Xue ZY, Li GF, Hao LY, Zhu LJ, Li YQ, Ding HL, Cao JL.Hydroxymethylation of microRNA-365-3p Regulates Nociceptive Behaviors via Kcnh2.J Neurosci. 2016;36(9):2769-2781.

2. LaMonica K, Ding HL, Artinger KB. prdm1a functions upstream of itga5 in zebrafish craniofacial development. Genesis. 2015; 53(3-4):270-277.

3. Yang JX, Hua L, Li YQ, Jiang YY, Han D, Liu H, Tang QQ, Yang XN, Yin C, Hao LY, Yu L, Wu P, Shao CJ, Ding HL, Zhang YM, Cao JL. Caveolin-1 in the anterior cingulate cortex modulates chronic neuropathic pain via regulation of NMDA receptor 2B subunit. J Neurosci. 2015;35(1):36-52.

4. Liu H, Yan WW, Lu XX, Zhang XL, Wei JQ, Wang XY, Wang T, Wu T, Cao J, Shao CJ, Zhou F, Zhang HX, Zhang P, Zang T, Lu XF, Cao JL, Ding HL, Zhang LC. Role of the cerebrospinal fluid-contacting nucleus in the descending inhibition of spinal pain transmission.Exp Neurol. 2014;261:475-485.

5. Ding HL, Clouthier DE, Artinger KB. Redundant roles of PRDM family members in zebrafish craniofacial development.DevDyn 2013; 242(1):67-79.

6．Ding HL, Ryder JW, Stull JT, Kamm KE. Signaling processes for initiating smooth muscle contraction upon neural stimulation. J Biol Chem. 2009; 284(23):15541-15548.

7．Mizuno Y, Isotani E, Huang J, Ding H, Stull JT, Kamm KE. Myosin light chain kinase activation and calcium sensitization in smooth muscle in vivo.Am J Physiol Cell Physiol. 2008;295(2):C358-364.

8．Ding HL, Zhu HF, Dong JW, Zhu WZ, Yang WW, Yang HT, Zhou ZN. Inducible nitric oxide synthase contributes to intermittent hypoxia against ischemia/reperfusion injury. ActaPharmacol Sin. 2005;26(3):315-322.

9．Cao JL, Ding HL, He JH, Zhang LC, Duan SM, Zeng YM. The spinal nitric oxide involved in the inhibitory effect of midazolam on morphine-induced analgesia tolerance. PharmacolBiochemBehav. 2005;80(3):493-503.

10．Cao JL, He JH, Ding HL, Zeng YM. Activation of the spinal ERK signaling pathway contributes naloxone-precipitated withdrawal in morphine-dependent rats. Pain 2005;118(3):336-349.

11．Ding HL, Zhu HF, Dong JW, Zhu WZ, Zhou ZN. Intermittent hypoxia protects the rat heart against ischemia/reperfusion injury by activating protein kinase C. Life Sci. 2004;75(21):2587-2603.

12．Zhu WZ, Dong JW, Ding HL, Yang HT, Zhou ZN. Postnatal development in intermittent hypoxia enhances resistance to myocardial ischemia/reperfusion in male rats. Eur J Appl Physiol. 2004;91(5-6):716-722.

13．Dong JW, Zhu HF, Zhu WZ, Ding HL, Ma TM, Zhou ZN. Intermittent hypoxia attenuates ischemia/reperfusion induced apoptosis in cardiac myocytes via regulating Bcl-2/Bax expression. Cell Res 2003;13(5):385-391.

14．Zhu HF, Dong JW, Zhu WZ, Ding HL, Zhou ZN. ATP-dependent potassium channels involved in the cardiac protection induced by intermittent hypoxia against ischemia/reperfusion injury.Life Sci 2003;73(10):1275-1287.

15．Ding HL, Zeng YM, Li XD, Jiang WP, Duan SM. Effects of ropivacaine on sodium, calcium, and potassium currents in guinea pig ventricular myocytes.ActaPharmacol Sin 2002;23(1):50-54.

16．Cao JL, Ding HL, Zhang LC, Duan SM, Zeng YM. Pretreatment with midazolam suppresses morphine withdrawal response in mice and rats. ActaPharmacol Sin 2002;23(8):685-690.

 

联系方式

丁海雷

 

电话: +86-516-83262703 (o)

E-Mail: haileimdar        yahoo.com

地址: 221004徐州市铜山路209号徐州医科大学科技楼D座D429室